1373432-13-3

Upstream product

• 1202032-99-2 (R)-3-(tert-butyl)-3-oxido-2H-benzo[d][1,3]oxaphosphol-4-yl trifluoromethanesulfonate 
• 1373432-34-8 (R)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3 dihydrobenzo[d][1,3]oxaphosphole-3-oxide 
• 100-39-0 benzyl bromide 
• 1373432-38-2 (2S,3R)-2-benzyl-3-tert-butyl-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole oxide 
• 23112-96-1 (2,6-dimethoxyphenyl)boronic acid 

Relevant academic research and scientific papers

Ligand-accelerated stereoretentive Suzuki-Miyaura coupling of unprotected 3,3′-dibromo-BINOL

An efficient synthesis of the enantiomerically pure 3,3′-bis-arylated BINOL derivatives is accomplished through the palladium-catalyzed Suzuki-Miyaura coupling of the unprotected 3,3′-dibromo-BINOL with complete retention of enantiopurity. The active cata

Efficient chiral monophosphorus ligands for asymmetric Suzuki-Miyaura coupling reactions

A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki-Miyaura coupling reactions, enabling the construction of an array of chiral biaryl products in high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety in these chiral biaryl products allows facile derivatization for further synthetic applications. A computational study has revealed that a π-π interaction between the two coupling partners can enhance the enantioselectivity of the coupling reaction.