1373543-39-5Relevant articles and documents
An efficient enantioselective synthesis of florfenicol based on sharpless asymmetric dihydroxylation
Wang, Zhong-Hua,Zheng, Chen,Li, Feng,Zhao, Lei,Chen, Fen-Er,He, Qiu-Qin
, p. 699 - 704 (2012/04/04)
An efficient and highly enantioselective synthesis of florfenicol- via a new intermediate threo-dihydroxy ester, with a Sharpless asymmetric dihydroxylation as the key step, is reported. A ring-opening/reduction strategy avoids the formation of a chlorinated byproduct that occurs in Schumachers phenyloxazoline procedure. The overall yield of florfenicol by this new process is 23% based on 4-(methylsulfonyl)benzaldehyde. Georg Thieme Verlag Stuttgart · New York.