186457-49-8

Basic information

• Product Name: 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-
• Synonyms: 2-Propenoicacid, 3-[4-(methylsulfonyl)phenyl]-, methyl ester, (E)-; AN 20519
• CAS NO: 186457-49-8
• Molecular Formula: C11H12 O4 S
• Molecular Weight: 240.28
• Mol File: 186457-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-(186457-49-8)
• EPA Substance Registry System: 2-Propenoic acid,3-[4-(methylsulfonyl)phenyl]-, methyl ester, (2E)-(186457-49-8)

Safety Data

• Hazardous Substances Data: 186457-49-8(Hazardous Substances Data)

Upstream product

• 5398-77-6 para-methanesulfonylbenzaldehyde 
• 67-56-1 methanol 
• 5345-30-2 3-(4-methanesulfonyl-phenyl)-acrylic acid 

Downstream Products

• 1373543-39-5 methyl (2R,3S)-2,3-dihydroxy-3-[4-(methylsulfonyl)phenyl]propanoate 

Relevant articles and documents

An efficient enantioselective synthesis of florfenicol based on sharpless asymmetric dihydroxylation

An efficient and highly enantioselective synthesis of florfenicol- via a new intermediate threo-dihydroxy ester, with a Sharpless asymmetric dihydroxylation as the key step, is reported. A ring-opening/reduction strategy avoids the formation of a chlorinated byproduct that occurs in Schumachers phenyloxazoline procedure. The overall yield of florfenicol by this new process is 23% based on 4-(methylsulfonyl)benzaldehyde. Georg Thieme Verlag Stuttgart · New York.