1373544-72-9

Upstream product

• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 1373546-39-4 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile 
• 21803-75-8 4-amino-3-chlorobenzonitrile 
• 3132-99-8 m-bromobenzoic aldehyde 

Relevant academic research and scientific papers

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

TETRAHYDROQUINOLINE DERIVATIVES USED AS AMPK ACTIVATORS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.