1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid
CAS No.:1373544-72-9
Molecular Formula:C₂₂H₂₂ClN₃O₂
Molecular Weight:395.889
Hs Code.:

Synonyms:1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

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Chemical Property of 1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

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Technology Process of 1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

There total 3 articles about 1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.1%

: 22059-21-8
aminocyclopropane-1-carboxylic acid

: 1373546-39-4
2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

: 1373544-72-9
1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

Guidance literature:: aminocyclopropane-1-carboxylic acid; 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile; With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; at 120 ℃; for 16h;

With ammonium chloride; In water; dimethyl sulfoxide; ethyl acetate; at 20 ℃;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373544-72-9
1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ytterbium(III) triflate / acetonitrile / 18 h / 85 °C / sealed tube

2.1: potassium carbonate / copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C

2.2: 20 °C

With potassium carbonate; copper(l) iodide; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 21803-75-8
4-amino-3-chlorobenzonitrile

: 1373544-72-9
1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ytterbium(III) triflate / acetonitrile / 18 h / 85 °C / sealed tube

2.1: potassium carbonate / copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C

2.2: 20 °C

With potassium carbonate; copper(l) iodide; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;