1373617-83-4Relevant academic research and scientific papers
Facile and highly diastereoselective synthesis of 3-aminooxindoles via AgOAc-catalyzed vinylogous Mannich reaction
Shi, Yu-Hua,Wang, Zheng,Shi, Ying,Deng, Wei-Ping
, p. 3649 - 3653 (2012/06/18)
A novel AgOAc-catalyzed vinylogous Mannich reaction between easily prepared imines 1 derived from isatins and trimethylsilyloxyfuran 2 (TMSOF) was developed. This method provided a facile synthetic route to get access to synthetically useful quaternary 3-aminooxindole in excellent yields (94-99%) and diastereoselectivities (>99:1).
