1373771-91-5Relevant articles and documents
Rational design and synthesis of novel Syk-kinase inhibitors
Zeifman, Alexey A.,Titov, Ilya Yu.,Svitanko, Igor V.,Rakitina, Tatiana V.,Lipkin, Aleksey V.,Stroylov, Viktor S.,Stroganov, Oleg V.,Novikov, Fedor N.,Chilov, Ghermes G.
, p. 73 - 74 (2012/07/03)
Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC50/sub