885702-32-9Relevant articles and documents
Rational design and synthesis of novel Syk-kinase inhibitors
Zeifman, Alexey A.,Titov, Ilya Yu.,Svitanko, Igor V.,Rakitina, Tatiana V.,Lipkin, Aleksey V.,Stroylov, Viktor S.,Stroganov, Oleg V.,Novikov, Fedor N.,Chilov, Ghermes G.
scheme or table, p. 73 - 74 (2012/07/03)
Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC50/sub
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
Choi, Ha-Soon,Wang, Zhicheng,Richmond, Wendy,He, Xiaohui,Yang, Kunyong,Jiang, Tao,Sim, Taebo,Karanewsky, Donald,Gu, Xiang-Ju,Zhou, Vicki,Liu, Yi,Ohmori, Osamu,Caldwell, Jeremy,Gray, Nathanael,He, Yun
, p. 2173 - 2176 (2007/10/03)
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their prelimi