1373774-63-0Relevant academic research and scientific papers
Synthesis of ethyl and phenyl amido(ethoxyphenylalaninyl)phosphate compounds
Jalalifar,Javidan,Khalikov
, p. 1097 - 1100 (2012/10/07)
The synthetic route for preparation of three phosphoramides containing amino acid and their precursors in good yield and mild conditions is reported. This involved the synthesis of the ethyl and phenyl phosphorodichloridate and its reaction with bis(β-chloroethyl) amine or diethylamine, followed by the reaction of the products with phenyl alanine ethyl ester hydrochloride. In all the three compounds, because of the presence of chiral centre, the final products were obtained as a mixture of two diastereoisomers, which can be determined using 31P NMR and TLC methods. The structures of all the prepared compounds were confirmed by 1H NMR, 31P NMR, 13C NMR spectroscopy.
