1373946-36-1

Basic information

• Product Name: 2-((4-(4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)amino)-N-(6-bromobenzo[d]thiazol-2-yl)acetamide
• CAS NO: 1373946-36-1
• Molecular Weight: 663.685
• Mol File: 1373946-36-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((4-(4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)amino)-N-(6-bromobenzo[d]thiazol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-(4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)amino)-N-(6-bromobenzo[d]thiazol-2-yl)acetamide(1373946-36-1)
• EPA Substance Registry System: 2-((4-(4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)phenyl)amino)-N-(6-bromobenzo[d]thiazol-2-yl)acetamide(1373946-36-1)

Safety Data

• Hazardous Substances Data: 1373946-36-1(Hazardous Substances Data)

Upstream product

• 1373945-98-2 4-(4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)aniline 
• 3427-31-4 N-(6-bromobenzo[d]thiazol-2-yl)-2-chloroacetamide 
• 1373945-97-1 2-chloro-4,6-bis(3,5-dimethylpiperidin-1-yl)-1,3,5-triazine 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 106-40-1 4-bromo-aniline 
• 5089-33-8 2-(4-bromophenyl)-1,1,1,3,3,3-hexamethyldisilazane 

Relevant articles and documents

Synthesis of potential antitubercular and antimicrobial s-triazine-based scaffolds via Suzuki cross-coupling reaction

Two series of bis(3,5-dimethylpiperidinyl)-1,3,5-triazinyl)-N-(phenyl/ benzothiazolyl)-acetamides were synthesized so as to investigate their antimicrobial and antimycobacterial actions. Intermediate 4-(4,6-bis(3,5- dimethylpiperidin-1-yl)-1,3,5-triazin-2-yl)aniline was synthesized by palladium-catalyzed Suzuki cross-coupling reaction to furnish C-C bond formation to s-triazine ring. Pharmacological screening against eight bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, and S. flexneri), four fungi (A. niger, A. fumigatus, A. clavatus, and C. albicans), and Mycobacterium tuberculosis H37Rv was examined and the effects of various substituents on biological profiles (MIC, 1.56-50 μg/mL) of final analogues were investigated. Four (8c, 8i, 9d, 9j) of the final analogues displayed antimycobacterial activity (3.12-6.25 μg/mL) equipotent to standard drugs.