13740-67-5Relevant articles and documents
Electrophilic chemistry of biologically important α-ketoacids
Klumpp, Douglas A.,Lau, Siufu,Garza, Manuel,Schick, Brian,Kantardjieff, Katherine
, p. 7635 - 7637 (1999)
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Superacid-promoted hydroxyalkylation of 1,2-indandiones
Tracy, Adam F.,Abbott, Matthew P.,Klumpp, Douglas A.
, p. 2171 - 2177 (2013/07/25)
1,2-Indandione reacts efficiently with arenes to give 2,2-diaryl-1- indanones by the hydroxyalkylation reaction. The Bronsted superacid CF3SO3H (triflic acid) is an effective catalyst for these condensation reactions. The requisite 1
Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds
Pletnev, Alexandre A.,Larock, Richard C.
, p. 9428 - 9438 (2007/10/03)
An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.