137420-52-1

Basic information

• Product Name: 2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester
• Synonyms: 2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester;Bromo(3-chlorophenyl)acetic acid methyl ester;Methyl α-bromo-3-chlorobenzeneacetate;Methyl bromo(3-chlorophenyl)acetate
• CAS NO: 137420-52-1
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 264
• Mol File: 137420-52-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 280℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.567
• CAS DataBase Reference: 2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester(137420-52-1)
• EPA Substance Registry System: 2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester(137420-52-1)

Safety Data

• Hazardous Substances Data: 137420-52-1(Hazardous Substances Data)

Usage

General Description

2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester is a chemical compound with the molecular formula C9H8BrClO2. It is a methyl ester derivative of 2-(3-Chlorophenyl)-2-bromoacetic acid, and is commonly used as a building block in organic synthesis. 2-(3-Chlorophenyl)-2-bromoacetic acid methyl ester is often utilized in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is a white to off-white solid, and is soluble in organic solvents such as ethanol and dimethyl sulfoxide. The compound is also known to have potential applications in the field of medicinal chemistry due to its unique structural properties.

Upstream product

• 53088-68-9 methyl 3-chlorophenylacetate 
• 67-56-1 methanol 
• 3381-74-6 α-Bromo-(3-chlorophenyl)acetic acid 
• 1878-65-5 3-chlorophenylacetic acid 
• 587-04-2 m-Chlorobenzaldehyde 
• 16273-37-3 3-chloromandelic acid 
• 13305-18-5 (3-chlorophenyl)hydroxyacetic acid methyl ester 

Downstream Products

• 160462-36-2 methyl 2-(2,6-Dipropyl-4-Hydroxymethylphenoxy)-2-(3-Chlorophenyl)Acetate 
• 181040-20-0 methyl (RS)-(3-chlorophenyl)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]acetate 
• 869347-68-2 (+/-)-5,6-dihydro-5-(3-chlorophenyl)-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one 
• 869347-67-1 5-(3-chloro)phenyl-4H-pyrrolo[1,2-a][1]benzoxazepin-4-one 
• 160462-37-3 methyl 2-(2,6-Dipropyl-4-Bromomethylphenoxy)-2-(3-Chlorophenyl)Acetate 
• 1105624-44-9 2-(3-chlorophenyl)-2-((3,4-dimethylphenyl)amino)acetic acid 

Relevant articles and documents

[2,3]-Sigmatropic rearrangements of didehydropiperidinium ylids

The [2,3]-sigmatropic rearrangements of ammonium ylids derived from 1,2,5,6-tetrahydropyridine have been studied: both rearrangement and elimination processes are observed, with rearrangement favoured when aprotic solvents are used in the reaction. The presence of anion-stabilizing substituents on the nucleophilic carbon atom of the intermediate ylid species involved in the tranformation also engenders rearrangement; when certain aryl substituents or two anion-stabilizing groups are present, elimination is not observed, and electron-donating ylid substituents retard rearrangement whilst enhancing elimination.

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.

NOVEL OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS

The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1 -phosphate receptors.