137420-62-3

Upstream product

• 589-18-4 4-Methylbenzyl alcohol 
• 18793-81-2 methyl 2-phenyl-2-(2-tosylhydrazono)acetate 
• 34921-09-0 diethyl (4-methylbenzyl) phosphate 
• 51491-68-0 2-phenylacrylyl chloride 
• 492-38-6 2-phenylacrylic acid 
• 1507347-50-3 2-phenyl-N-(quinolin-8-yl)-acrylamide 
• 5720-05-8 4-methylphenylboronic acid 
• 212315-75-8 methyl (Z)-3-iodo-2-phenyl-2-propenoate 

Relevant academic research and scientific papers

Pd-Catalyzed Coupling of N-Tosylhydrazones with Benzylic Phosphates: Toward the Synthesis of Di- or Tri-Substituted Alkenes

This study shows that various di- and tri-substituted alkenes with high chemoselectivity were obtained in good to high yields by coupling N-tosylhydrazones (NTHs) with benzylic phosphates as electrophilic partners. The obtained new catalytic system consis

Stereoselective synthesis of Z-vinylsilanes via palladium-catalyzed direct intermolecular silylation of C(sp2)-H bonds

An efficient and convenient palladium-catalyzed direct intermolecular silylation of C(sp2)-H bonds by using disilanes as the silicon source with the assistance of a readily removable bidentate directing group is reported. This strategy provided a regio- and stereoselective protocol for exclusive synthesis of Z-vinylsilanes with reasonable to excellent yields and good functional group compatibility. Silylation of the isolated palladacycle intermediate revealed the Z-stereoselective pathway. Moreover, the practicality and effectiveness of this method were illustrated by a gram-scale experiment and further functionalization of the silylation product.

ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED PYRIDOIMIDAZOLYL RING

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. STR1