1374348-09-0

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 51039-53-3 2-phenyl-5-bromo-1,3,4-oxadiazole 
• 613-94-5 benzoic acid hydrazide 
• 459-57-4 4-fluorobenzaldehyde 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 

Relevant academic research and scientific papers

Synthesis of 2-alkynyl 1,3,4-oxadiazoles by palladium-catalyzed cross- coupling reaction 1

Several 2-alkynyl 1,3,4-oxadiazoles have been synthesized efficiently by employing palladium-catalyzed cross-coupling under Sonogashira reaction conditions. This reaction has been applied for the first time for the preparation of oxadiazole derivatives. T

Copper-mediated C-H activation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes using PEG-400 as a solvent medium: Distinct approach for the alkynylation of 1,3,4-oxadiazoles

The direct C-H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73-86%) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly. The direct C-H alkynylation of 1,3,4-oxadiazoles with 1,1-dibromo-1-alkenes has been accomplished by using a combination of CuBr/LiOtBu in PEG-400 (a green solvent) at 80 °C. The products were formed in high yields (73-86%) in 2 h. No additional ligand or volatile solvent was required and the conversion was ecofriendly. Copyright