1374349-40-2Relevant academic research and scientific papers
Direct [11C]Methylation of Amines from [11C]CO2 for the Synthesis of PET Radiotracers
Liger, Fran?ois,Eijsbouts, Ture,Cadarossanesaib, Florence,Tourvieille, Christian,Le Bars, Didier,Billard, Thierry
, p. 6434 - 6438 (2015)
[11C]Methylation (t1/2 = 20.4 min) is a main labeling strategy for the development of PET (positron emission tomography) radiotracers. A straight radiomethylation of amines with cyclotron-produced 11CO2 has been developed to obtain various radiolabeled compounds with good radiochemical yields. This strategy is a new approach to simplifying radiolabeling processes and transpositions onto automatic synthesizers and has been applied to the synthesis of radiolabeled drugs and a PET radiotracer used in the study of Alzheimer's disease. From producer to consumer, no intermediate: Direct [11C]methylation of amines with cyclotron-produced 11CO2, and without intermediate transformations, provides a simpler entry to various PET radiotracers, such as β-amyloid radioligand [11C]PIB.
Rapid room-temperature 11C-methylation of arylamines with [ 11C]methyl iodide promoted by solid inorganic-bases in DMF
Cai, Lisheng,Xu, Rong,Guo, Xuelei,Pike, Victor W.
experimental part, p. 1303 - 1310 (2012/04/04)
[11C]Methyl iodide is the most widely used reagent for labeling radiotracers with carbon-11 (t1/2 = 20.4 min) for molecular imaging with positron emission tomography. However, some substrates for labeling, especially primary arylamin
