137449-21-9

Upstream product

• 66033-92-9 6-hydroxy-3-methyl-1,2-benzisoxazole 
• 106-89-8 epichlorohydrin 
• 2373-31-1 6-hydroxy-4-methyl-chromen-2-one 
• 146463-53-8 6-Ethyl-4-methyl-7-oxiranylmethoxy-chromen-2-one 
• 125733-45-1 4,8-Dimethyl-7-oxiranylmethoxy-chromen-2-one 
• 155259-84-0 4-methyl-6-[(oxiran-2-yl)methoxy]-2H-1-benzopyran-2-one 

Relevant academic research and scientific papers

Synthesis of heteroaryloxyhydroxypropanes and their PCA activities

1-(Substituted coumarinoxy)-3-substituted coumarinoxy/benzisoxazoloxy)-2-hydroxypropane (1-15) have been synthesised by treating substituted hydroxycoumarins and 6-hydroxy-3-methylbenzisoxazole with epichlorohydrin and found to possess PCA activities.

Synthesis of 1,3-bis(heteroaryloxy)-2-hydroxypropanes as symmetrical analogs of DSCG using phase transfer catalyst and their pharmacological activities

1,3-Bis(coumarinoxy)-2-hydroxypropanes (I-III), 1,3-bis(benzisoxazoloxy)-2-hydroxypropanes (IV) and 1,3-bis(benzofuranoxy)-2-hydroxypropanes (V) have been synthesised by treating substituted hydroxycoumarins, benzisoxazoles and benzofurans respectively with epoxide in the presence of a phase transfer catalyst, and found to possess passive cutaneous anaphylaxis and antiallergic activities.