1374560-91-4Relevant academic research and scientific papers
Synthesis of difluoromethyl-containing α-acyloxycarboxamide derivatives through a Passerini reaction and desulfonylation
Wu, Jingjing,Zhao, Wenwen,Cao, Song
experimental part, p. 1380 - 1387 (2012/03/27)
A series of difluoromethyl-containing α-acyloxycarboxamide derivatives were synthesized through a Passerini reaction of acids, aldehydes, and phenylsulfanyl-protected difluorinated isocyanide followed by meta-chloroperoxybenzoic acid mediated oxidation and the removal of the phenylsulfonyl protecting group. The unexpected formation of deacylation products from the reaction between the Passerini products and Bu 3SnH/azobis(isobutyronitrile) was also reported. A new approach to the synthesis of difluoromethyl-containing α-acyloxycarboxamide derivatives through a Passerini reaction followed by meta-chloroperoxybenzoic acid mediated oxidation and removal of thephenylsulfonyl group was developed. The formation of deacylation products from the reaction between the Passerini products and Bu3SnH/azobis(isobutyronitrile) was also reported. Copyright
