137460-62-9

Basic information

• Product Name: methyl (2R,3S)-2,3,4-trihydroxybutanoate
• Synonyms: methyl (2R,3S)-2,3,4-trihydroxybutanoate
• CAS NO: 137460-62-9
• Molecular Weight: 150.131
• Mol File: 137460-62-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (2R,3S)-2,3,4-trihydroxybutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2R,3S)-2,3,4-trihydroxybutanoate(137460-62-9)
• EPA Substance Registry System: methyl (2R,3S)-2,3,4-trihydroxybutanoate(137460-62-9)

Safety Data

• Hazardous Substances Data: 137460-62-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 50-81-7 ascorbic acid 
• 146-75-8 sodium L-ascorbate 

Relevant articles and documents

Substrate-like water soluble lipase inhibitors from Filipendula kamtschatica

Filipendula kamtschatica is a plant utilized as a traditional medicine by Ainu people in Japan, but its chemical constituents are not much studied. Pancreatic lipase inhibitors are a promising tool for the treatment of obesity. We searched for natural lipase inhibitors from F. kamtschatica and two new compounds were isolated along with the known flavonoid glycoside. The structure elucidation of new compounds revealed these two to be 2-O-caffeoyl-4-O-galloyl- l-threonic acid and 3-O-caffeoyl-4-O-galloyl-l-threonic acid, which can be recognized as a pancreatic lipase's substrate-like structure. The isolated compounds all showed an inhibitory activity against porcine pancreatic lipase and one of the isomer, 3-O-caffeoyl-4-O-galloyl-l-threonic acid, possessed the most potent activity with IC50 value showing an order lower value compared to others. The substrate-like structure of the new compounds seemed to be important for their activity.