1374639-75-4

Basic information

• Product Name: LEE011 (succinate)
• Synonyms: LEE011 (succinate);7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate;LEE-011 succinate salt, Ribociclib succinate salt;Ribociclib succinate
• CAS NO: 1374639-75-4
• Molecular Formula: C27H36N8O5
• Molecular Weight: 552.62534
• Mol File: 1374639-75-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: LEE011 (succinate)(CAS DataBase Reference)
• NIST Chemistry Reference: LEE011 (succinate)(1374639-75-4)
• EPA Substance Registry System: LEE011 (succinate)(1374639-75-4)

Safety Data

• Hazardous Substances Data: 1374639-75-4(Hazardous Substances Data)

Usage

Uses

LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.

Upstream product

• 110-15-6 succinic acid 
• 1211441-98-3 (7-cyclopentyl-Ν,Ν-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo [2,3-d]pyrimidine-6-carboxamide) 
• 1195-08-0 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde 
• 1211443-58-1 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 
• 1374639-78-7 N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide 
• 571189-16-7 4-(6-nitropyridin-3-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 39856-50-3 5-bromo2-nitropyridine 
• 571188-59-5 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 
• 1211443-61-6 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide 
• 1374639-77-6 (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol 
• 1374639-76-5 3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol 
• 733039-20-8 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine 
• 1003-03-8 Cyclopentamine 

Relevant articles and documents

POLYMORPHS OF 7-CYCLOPENTYL-N,N-DIMETHYL-2-{[5-(PIPERAZIN-1-YL) PYRIDIN-2-YL]-AMINO}-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCESS FOR THE PREPARATION THEREOF

The present invention relates to novel crystalline forms of butanedioic acid 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide of formula-1a and process for preparation thereof. The present invention also relates to a process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide. Further, the present application also relates to acid addition salts of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide and process for the preparation thereof.

Polymorphic substances of ribosinil monosuccinate and preparation method and use thereof

The invention relates to novel crystal forms of a compound mono-succinate represented by a formula I and a preparation method of the novel crystal. Specifically, the invention provides a plurality ofnew crystal forms of the compound mono-succinate represented by the formula I and a preparation method thereof, and the new crystal forms have the properties of excellent solubility, lower hygroscopicity, better stability and the like.

Crystal form of and preparation method and application thereof (by machine translation)

The invention relates to a crystal form of, a preparation method and an application thereof. , The invention provides a plurality of novel crystal forms and a preparation method thereof, and the novel crystal forms disclosed by the invention have excellent solubility and the like. (by machine translation)