1211443-61-6

Basic information

• Product Name: 7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-
• Synonyms: 7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-;2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxaMide;RIBOCICLIB INT;Ribociclib-1;7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide;2-chloro-7-cyclopentyl-N,N-diMethyl-7H-pyrrolo[2,3-d]pyriMidine-6-arboxaMide;2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide;EOS-60967
• CAS NO: 1211443-61-6
• Molecular Formula: C₁₄H₁₇ClN₄O
• Molecular Weight: 292.76398
• EINECS: 1592732-453-0
• Mol File: 1211443-61-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Vapor Pressure: 0-0Pa at 20-25℃
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.78±0.30(Predicted)
• CAS DataBase Reference: 7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-(1211443-61-6)
• EPA Substance Registry System: 7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl-(1211443-61-6)

Safety Data

• Hazardous Substances Data: 1211443-61-6(Hazardous Substances Data)

Usage

General Description

7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 2-chloro-7-cyclopentyl-N,N-dimethyl is a chemical compound with the molecular formula C14H17ClN4O. It is a derivative of pyrrolopyrimidine and is specifically substituted with a chlorine atom at the 2-position and a cyclopentyl and two methyl groups at the 7-position. 7H-Pyrrolo[2,3-d]pyriMidine-6-carboxaMide, 2-chloro-7-cyclopentyl-N,N-diMethyl- has potential pharmacological activities and can be used for research purposes in the pharmaceutical industry. It may have interactions with various biological targets and pathways and could be studied for its potential therapeutic applications.

Upstream product

• 733039-20-8 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine 
• 2682-34-0 N,N-dimethylpropynamide 
• 1211443-58-1 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 
• 506-59-2 N,N-dimethylammonium chloride 
• 1374639-77-6 (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol 
• 124-40-3 dimethyl amine 

Downstream Products

• 1374639-78-7 N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide 
• 1374639-75-4 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate 

Relevant articles and documents

Synthesis method of ribociclib intermediate product and intermediate compound thereof

The invention discloses a synthesis method of a ribociclib intermediate product, which comprises the following steps: by using barbituric acid as a starting material, carrying out chlorination and formylation to obtain a compound 2; and performing condens

CDK9 inhibitor, preparation method and application thereof

The invention provides a CDK9 inhibitor, the CDK9 inhibitor is a pyrimidopyrrole kinase inhibitor, and the chemical structural general formula of the CDK9 inhibitor is shown as the formula I in the specification, the CDK9 inhibitor is the pyrimidopyrrole kinase inhibitor, the protein target adapted to the pyrimidopyrrole kinase is serine/threonine kinase CDK9. The CDK9 inhibitor shows relatively high specificity and low cytotoxicity, and the CDK9 inhibitor which is used for preventing or treating tumor growth and metastasis, has selectivity on CDK9, and is small in toxic and side effects and strong in action effect is provided, so that the CDK9 inhibitor is used for regulating and controlling the biological function of CDK9 and inhibiting the growth and proliferation processes of tumors.

Synthesis method of anti-tumor drug ribociclib

The invention relates to a synthesis method of an anti-tumor drug ribociclib. The method mainly comprises the steps of carrying out a reaction between 4-(6-amino-3-pyridyl)-1-piperazinyl tert-butyl formate and 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrol