1374667-32-9Relevant academic research and scientific papers
Synthesis of 2-oxo-acetamidines via copper-catalyzed oxidative cross-coupling of Α-amino ketone compounds with amines
Wang, Pengjie,Xiong, Yi,Qin, Yiqun,Zhang, Jiajia,Yi, Niannian,Xiang, Jiannan,Deng, Wei
, (2019)
A general and efficient method for the synthesis of 2-oxo-acetamidines via copper-catalyzed oxidative cross-coupling of amines with α-amino ketone compounds was achieved. In this reaction, the C ? N bond of α-amino ketone is broken and new C ? N and C[dbnd]N bonds are constructed in one single transformation. This reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.
Method for synthesizing amidine compound by catalyzing and amidating copper (II) with aryl methyl ketone
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Paragraph 0116-0123, (2020/10/12)
The invention discloses a method for synthesizing amidine compounds through oxidative amidation of aryl methyl ketone under the catalysis of copper (II). The method comprises the following steps: in an oxygen-containing atmosphere and in an organic carboxylate/DMSO mixed system, performing a reaction on the aryl methyl ketone and aryl primary amine under the catalysis of divalent copper salt, or performing a reaction on the aryl methyl ketone and the aryl primary amine and secondary amine under the catalysis of the divalent copper salt to obtain the amidine compounds. By the method, the aryl methyl ketone and amine compounds are used as raw materials for producing the amidine compounds through the one-step reaction; the method has the characteristics of a simple step, low cost and the like, and is conducive to industrial production.
Synthesis method of amidine compound
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Paragraph 0133-0140, (2018/03/01)
The invention discloses a synthesis method of an amidine compound. The synthesis method comprises the following step of, in an oxygen-containing atmosphere and an organic carboxylate /polar aprotic solvent mixed system, performing reaction on arylmethyl ketone or aromatic heterocyclic methyl ketone and primary amine under catalysis of a copper salt and/or a cuprous salt, or performing reaction onthe arylmethyl ketone or the aromatic heterocyclic methyl ketone, the primary amine and secondary amine under catalysis of the copper salt and/or the cuprous salt to obtain the amidine compound. For producing the amidine compound with one-step reaction by taking the arylmethyl ketone or the aromatic heterocyclic methyl ketone and an amine compound as raw materials, the method has the characteristics of simple steps, low cost and the like and is beneficial to industrial production.
Method for synthesizing amidine compound through direct amidination of SP-H of aromatic methylketone
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Paragraph 0126-0133, (2018/04/03)
The invention discloses a method for synthesizing an amidine compound through direct amidination of SP-H of aromatic methylketone. The method is characterized in that the aromatic methylketone or heteroaromatic methylketone reacts with aryl primary amine in a benzoate/polar aprotic solvent mixed system in an oxygen-containing atmosphere under the catalysis of a copper salt and/or a cuprous saltto obtain the amidine compound. The amidine compound is generated by direct oxidation amidation of the SP-H through a one-step reaction of the aromatic methylketone or heteroaromatic methylketoneused as a raw material. The method has the characteristics of simple step and low cost, and is beneficial for industrial production.
Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines
Chen, Chuang,Zhu, Menghua,Jiang, Lihui,Zeng, Zebing,Yi, Niannian,Xiang, Jiannan
supporting information, p. 8134 - 8139 (2017/10/10)
A general and mild method for the construction of a carbon-nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with α-aminocarbonyl compounds was achieved. Amines, either aliphatic primary amines, aromatic primary amines or secondary amines can be used as the starting materials. When R2 was different from R3, two isomers would be observed. Therefore, this reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.
Multiple oxidative dehydrogenative functionalization of arylacetaldehydes using molecular oxygen as oxidant leading to 2-oxo-acetamidines
Zhang, Chun,Zhang, Liangren,Jiao, Ning
supporting information; experimental part, p. 1293 - 1300 (2012/06/15)
A novel copper-catalyzed, multiple oxidative dehydrogenative functionalization of arylacetaldehydes leading to 2-oxo-acetamidine compounds has been developed. This transformation is highly efficient with dissociation of six hydrogens including two sp
