24259-15-2Relevant academic research and scientific papers
Design, Pharmacokinetic, and Pharmacodynamic Evaluation of a New Class of Soft Anticholinergics
Huang, Fenglei,Browne, Clinton E.,Wu, Whei-Mei,Juhasz, Attila,Ji, Fubao,Bodor, Nicholas
, p. 1681 - 1689 (2007/10/03)
Purpose. To design and evaluate a new class of soft anticholinergics with subtype selectivity. Methods. A new class of soft anticholinergics was designed based on the "inactive metabolite" approach. Four compounds were synthesized. The potency and soft na
N-Alkyl-nor-tropine esters of 2-phenyl-cyclohexenic acids as new bronchodilator agents. Effect of structural and conformational modifications on affinity for muscarinic receptors
Turbanti,Cerbai,Garzelli,Renzetti,Criscuoli,Subissi,Bramanti,Martinelli
, p. 449 - 462 (2007/10/02)
A series of N-alkyl-nor-tropine esters of 2-phenyl-2-cyclohexene-1-carboxylic, 2-phenyl-cyclohexanecarboxylic, and 2-phenyl-1-cyclohexene-1-acetic acids and their quaternary ammonium salts were synthesized and evaluated for bronchodilator activity by bind
