1374967-36-8

Basic information

• Product Name: (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid
• Synonyms: (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid
• CAS NO: 1374967-36-8
• Molecular Weight: 461.495
• Mol File: 1374967-36-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid(1374967-36-8)
• EPA Substance Registry System: (3R)-7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid(1374967-36-8)

Safety Data

• Hazardous Substances Data: 1374967-36-8(Hazardous Substances Data)

Upstream product

• 1380299-26-2 (3R)-methyl 7-((7-methoxy-2-oxo-2H-chromen-4-yl)methyl)-5-oxo-8-phenyl-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate 
• 62935-72-2 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid 
• 140-29-4 phenylacetonitrile 
• 5442-34-2 ethyl 2-phenylacetimidate hydrochloride 

Relevant articles and documents

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study

Pilicides prevent pili formation and thereby the development of bacterial biofilms in Escherichia coli. We have performed a comprehensive structure activity relationship (SAR) study of the dihydrothiazolo ring-fused 2-pyridone pilicide central fragment by varying all open positions. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) was used to distinguish active from inactive compounds in which polarity proved to be the most important factor for discrimination. A quantitative SAR (QSAR) partial least squares (PLS) model was calculated on the active compounds for prediction of biofilm inhibition activity. In this model, compounds with high inhibitory activity were generally larger, more lipophilic, more flexible and had a lower HOMO. Overall, this resulted in both highly valuable SAR information and potent inhibitors of type 1 pili dependent biofilm formation. The most potent biofilm inhibitor had an EC50 of 400 nM.