1374969-58-0

Basic information

• Product Name: 6-((1R,2S)-2-aminocyclohexylamino)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-5-fluoronicotinamide hydrochloride
• Synonyms: 6-((1R,2S)-2-aminocyclohexylamino)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-5-fluoronicotinamide hydrochloride
• CAS NO: 1374969-58-0
• Molecular Weight: 437.902
• Mol File: 1374969-58-0.mol

Chemical Properties

• CAS DataBase Reference: 6-((1R,2S)-2-aminocyclohexylamino)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-5-fluoronicotinamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-((1R,2S)-2-aminocyclohexylamino)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-5-fluoronicotinamide hydrochloride(1374969-58-0)
• EPA Substance Registry System: 6-((1R,2S)-2-aminocyclohexylamino)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-5-fluoronicotinamide hydrochloride(1374969-58-0)

Safety Data

• Hazardous Substances Data: 1374969-58-0(Hazardous Substances Data)

Upstream product

• 365996-30-1 tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate 
• 82671-02-1 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile 
• 1374969-60-4 C₂₅H₃₂FN₅O₅ 
• 1374969-59-1 C₂₅H₃₀FN₅O₄ 
• 1354251-15-2 tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate 

Relevant articles and documents

BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS

The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.