1354251-15-2

Basic information

• Product Name: tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate
• Synonyms: tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate
• CAS NO: 1354251-15-2
• Molecular Weight: 368.839
• Mol File: 1354251-15-2.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate(1354251-15-2)
• EPA Substance Registry System: tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate(1354251-15-2)

Safety Data

• Hazardous Substances Data: 1354251-15-2(Hazardous Substances Data)

Upstream product

• 1391731-16-0 C₈H₈O₃*C₁₁H₂₂N₂O₂ 
• 121282-70-0 (1S,2S)-2-tert-Butoxycarbonylamino-1-cyclohexanol 
• 82671-02-1 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile 
• 365996-30-1 tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate 

Downstream Products

• 1374969-65-9 C₂₁H₂₇FN₆O₂S 
• 1374969-59-1 C₂₅H₃₀FN₅O₄ 
• 1374969-72-8 tert-butyl (1S,2R)-2-(5-cyano-3-fluoro-6-(5-fluoropyridin-3-ylamino)pyridin-2-ylamino)cyclohexylcarbamate 
• 1374969-58-0 6-((1R,2S)-2-aminocyclohexylamino)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylamino)-5-fluoronicotinamide hydrochloride 
• 1374969-60-4 C₂₅H₃₂FN₅O₅ 
• 1374974-08-9 3-(6-((1R,2S)-2-aminocyclohexylamino)-3-carbamoyl-5-fluoropyridin-2-ylamino)-5-fluoropyridine-1-oxide 
• 1312691-34-1 tert-butyl ((1S,2R)-2-((7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)cyclohexyl)carbamate 

Relevant articles and documents

SOLID STATE FORMS OF FUSED HETEROAROMATIC PYRROLIDINONES

Disclosed are chemical entities which are inhibitors of spleen tyrosine kinase (SYK), namely, chemical entities comprising 6-((lR,2S)-2-aminocyclohexylamino)-7-fluoro-4-(1 -methyl-1H- pyrazol-4-yl)-lH-pyrrolo[3,4-c]pyridine-3(2H)-one and certain solid state forms thereof. Also disclosed are methods of using the chemical entities to treat disorders such as a cancer.

NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF

The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS

The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.