1374992-85-4Relevant academic research and scientific papers
1-Aminobenzocyclobutene-1-phosphonic Acid and Related Compounds as Inhibitors of Phenylalanine Ammonia-Lyase
Zoń, Jerzy,Miziak, Piotr
, (2017)
Five new geminal aminocycloalkanephosphonic acids (4 – 8) containing both an aromatic ring and a cycloalkane ring were synthesized and evaluated as potential inhibitors of buckwheat phenylalanine ammonia-lyase (PAL). Within the set of compounds which are related to 2-aminoindane-2-phosphonic acid (AIP, 3), a known powerful inhibitor of PAL, racemic 1-aminobenzocyclobutene-1-phosphonic acid (4), was six times weaker than AIP as an in vitro inhibitor of buckwheat PAL, but six times stronger than AIP as an in vivo inhibitor of phenylalanine-derived anthocyanin synthesis in buckwheat.
Dialkylation of diethyl ethoxycarbonylmethylphosphonate under microwave and solventless conditions
Gruen, Alajos,Blastik, Zsofia,Drahos, Laszlo,Keglevich, Gyoergy
, p. 107 - 113 (2014/04/03)
To further broaden the methods for the heterogeneous phase alkylation of CH acidic compounds, the dialkylation of diethyl ethoxycarbonylmethylphosphonate was studied in the presence of Cs2CO3 under microwave and solvent-free conditio
Microwave-assisted alkylation of diethyl ethoxycarbonylmethylphosphonate under solventless conditions
Gruen, Alajos,Blastik, Zsofia,Drahos, Laszlo,Keglevich, Gyoergy
experimental part, p. 241 - 246 (2012/07/28)
The reaction of diethyl ethoxycarbonylmethylphosphonate with a series of alkyl halides, under microwave (MW) and solventless conditions at 120°C, in the presence of Cs2CO3 and in the absence of a phase transfer catalyst afforded the corresponding monoalkylated products in yields of >70%. The thermal variant carried out in boiling acetonitrile was slow and led to incomplete conversions. In the MW method, the phase transfer catalyst is substituted by MW irradiation and there is no need for a solvent.
