1375070-75-9Relevant academic research and scientific papers
Enantioselective copper-catalyzed reductive coupling of alkenylazaarenes with ketones
Saxena, Aakarsh,Choi, Bonnie,Lam, Hon Wai
, p. 8428 - 8431 (2012/08/08)
Catalytic enantioselective methods for the preparation of chiral azaarene-containing compounds are of high value. By combining the utility of copper hydride catalysis with the ability of C=N-containing azaarenes to activate adjacent alkenes toward nucleophilic additions, the enantioselective reductive coupling of alkenylazaarenes with ketones has been developed. The process is tolerant of a wide variety of azaarenes and ketones, and provides aromatic heterocycles bearing tertiary-alcohol-containing side chains with high levels of diastereo- and enantioselection.
