1375081-89-2Relevant articles and documents
Asymmetric induction by (S)-4-isopropyl-1-phenylimidazolidin-2-thione in titanium-mediated aldol reactions and its application in enantioselective synthesis of (R)-baclofen
Khatik, Gopal L.,Khurana, Ravi,Kumar, Varun,Nair, Vipin A.
, p. 3123 - 3132 (2011/10/31)
The usefulness of (S)-4-isopropyl-1-phenylimidazolidin-2-thione as a chiral auxiliary in stereoselective propionate and acetate aldol reactions is discussed. Further, the enantioselective synthesis of (R)-baclofen by acetate aldol reaction using the chiral auxiliary was demonstrated. Georg Thieme Verlag Stuttgart New York.