1375149-23-7Relevant academic research and scientific papers
A short synthesis of Dronedarone
Piotrkowska, Barbara,Nerdinger, Sven,Schreiner, Erwin,Seli?, Lovro,Graczyk, Piotr P.
, p. 4330 - 4335 (2018)
A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH2CH2CH2NBu2) in a two-stage process in almost 55% overall yield. Our results represent significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required.
PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES
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Page/Page column 47, (2012/05/31)
The present invention relates to a process for the preparation of 3-aroyl -5- aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.
