73021-84-8

Upstream product

• 51767-39-6 4-(methylsulfonylamino)phenol 
• 51-78-5 p-aminophenol hydrochloride 
• 123-30-8 4-amino-phenol 

Downstream Products

• 856193-61-8 methanesulfonic acid-[3-(1-acetyl-2-oxo-propyl)-4-hydroxy-anilide] 
• 51767-39-6 4-(methylsulfonylamino)phenol 
• 76960-38-8 4-(dimethylamino)-N-(4-hydroxymethyl)methanesulfonylanilide 
• 76960-39-9 N-[4-(4-Dimethylamino-phenoxy)-phenyl]-methanesulfonamide 
• 10406-66-3 methanesulfonic acid p-phenetidide 
• 141626-36-0 dronedarone 
• 1375149-24-8 C₃₁H₄₆N₂O₆S 
• 1375149-23-7 C₃₁H₄₆N₂O₆S 
• 141625-93-6 2-(n-butyl)-3-(4-{3-[di(n-butyl)amino]propoxy}benzoyl)-5-(methanesulfonamido)benzofuran hydrochloride 
• 919966-54-4 N-(3-((1H-1,2,4-triazol-5-yl)thio)-4-hydroxyphenyl)methanesulfonamide 
• 1397749-85-7 phenyl 2-butyl-5-(methanesulfonamido)benzofuran-3-carboxylate 
• 1278585-70-8 N-[2-butyl-3-(4-hydroxybenzoyl)-1-benzofuran-5-yl]methanesulfonamide 
• 141625-93-6 dronedarone hydrochloride 
• 1329684-17-4 methyl-2-[2-hydroxy-5-(methanesulfonamido)phenyl]-3-oxoheptanoate 

Relevant academic research and scientific papers

PROCESS FOR SYNTHESIZING KETO-BENZOFURAN DERIVATIVES

The invention relates to a process for synthesizing benzofuran derivatives, in particular dronedarone of formula (D), comprising a step of Friedel-Crafts acylation starting from a sulfonamido-benzofuran ester intermediate.

KETOBENZOFURAN DERIVATIVES, METHOD FOR SYNTHESIZING SAME, AND INTERMEDIATES

The present disclosure relates to ketobenzofuran derivatives of the general formula (I): as well as to a method of synthesizing the same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.

Discovery of 4-amino-2-(thio)phenol derivatives as novel protein kinase and angiogenesis inhibitors for the treatment of cancer: Synthesis and biological evaluation. Part II

A novel series of 4-amino-2-(thio)phenol derivatives were well synthesized. The preliminary biological test revealed that several compounds displayed high specific protein kinase and angiogenesis inhibitory activities compared with previous work mainly because of the substitution of sulfonamide structure for amide fragment. Among which, compound 5i was identified to inhibit protein kinase B/AKT (IC50 = 1.26 μM) and ABL tyrosine kinase (IC 50 = 1.50 μM) effectively. Meanwhile, compound 5i demonstrated competitive in vitro antiangiogenic activities to Pazopanib in both human umbilical vein endothelial cell (HUVEC) tube formation assay and the rat thoracic aorta rings test.

Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives

The present invention relates to a process for the preparation of 3-aroyl-5-aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.

PROCESS FOR THE PREPARATION OF 3-AROYL-5-AMINOBENZOFURAN DERIVATIVES

The present invention relates to a process for the preparation of 3-aroyl -5- aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.

Synthesis of 5-substituted 2,3-dihydrobenzofurans in a one-pot oxidation/cyclization reaction

Variously substituted 2,3-dihydrobenzofurans have been synthesized according to a sequential one-pot oxidation/cyclization procedure between para-aminophenol derivatives and an azadiene.