87522-38-1Relevant academic research and scientific papers
Catalyst Controlled Divergent C4/C8 Site-Selective C-H Arylation of Isoquinolones
Lee, Soyoung,Mah, Shinmee,Hong, Sungwoo
, p. 3864 - 3867 (2015)
The catalyst-controlled C4/C8 site-selective C-H arylation of isoquinolones using aryliodonium salts as the coupling partners was developed. The C4-selective arylation was successfully achieved via an electrophilic palladation pathway. A completely differ
New reduction reaction of benzylic alcohols with acid and proof of the intermolecular hydride shift mechanism
Kihara, Masaru,Andoh, Jun-Ichi,Yoshida, Chiaki
, p. 359 - 372 (2007/10/03)
The new reduction reaction of the hydroxy groups of 4-hydroxy-4-phenyl- 1,2,3,4-tetrahydroisoquinolines (1) to the corresponding alkanes (2) with mineral and Lewis acids is reported. A stereoselective intermolecular hydride shift mechanism of the reduction was proved by reaction of the deuterated derivatives (14 and 15) of 1a with 10N HCl-C2H5OH and BBr3 in CH3CN.
A new synthetic route to 2-alkyl-4-aryl-1(2H)-isoquinolones and 2-alkyl-4-aryl-1,2,3,4-tetrahydroisoquinolines
Couture, Axel,Deniau, Eric,Grandclaudon, Pierre,Woisel, Patrice
, p. 4433 - 4448 (2007/10/03)
4-Aryl and heteroaryl-1(2H)-isoquinolones have been prepared by base promoted cyclization of phosphorylated o-aroyl and heteroaroyl benzamides. Subsequent reduction of the carbonyl and styryl functions of the annulated products has given rise to 4-aryl-1,2,3,4-tetrahydroisoquinolines.
A New Route to Diarylisoquinolones
Dodsworth, David J.,Pia-Calcagno, Maria,Ehrmann, E. Ursula,Quesada, Andres M.,Nunez S., Oswaldo,Sammes, Peter G.
, p. 1453 - 1458 (2007/10/02)
The lithium salts derived from position 3 of phthalides react with Schiff's bases to form a mixture of cis- and trans-2,3-disubstituted 4-hydroxy-3,4-dihydro-1(2H)-isoquinolones, the former isomer predominating.Acid-catalysed dehydration of the alcohols gives 2,4-disubstituted 1(2H)-isoquinolones, as a result of aryl group migration, whilst the cis-isomers, with methanesulphonyl chloride-pyridine as dehydrating agent, produce the 2,3-disubstituted 1(2H)-isoquinolones.
