1375304-89-4

Upstream product

• 2417-90-5 bromopropionitrile 
• 99-90-1 para-bromoacetophenone 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1370471-60-5 C₃₁H₂₄Br₂N₄O₆ 
• 1370471-03-6 3-azido-N-[1-(2-bromophenyl)-3-(4-bromophenyl)-3-oxopropyl]propanamide 
• 1375305-02-4 C₃₈H₃₄Br₃N₅O₅ 
• 1375305-00-2 C₃₈H₃₄Br₂ClN₅O₅ 
• 1375304-98-5 C₃₈H₃₄Br₂ClN₅O₅ 
• 1375304-96-3 C₃₈H₃₅Br₂N₅O₅ 
• 1375304-94-1 C₃₈H₃₄Br₃N₅O₅ 
• 1375304-92-9 C₃₈H₃₅Br₂N₅O₅ 

Relevant academic research and scientific papers

A copper-catalyzed multicomponent reaction and 'click strategy' for the stereoselective synthesis of a new series of oxazolone peptidomimetics with α-acylamino amide and β-amido ketone structures

A novel 'click ligation' strategy for the stereoselective synthesis of a medium-size library of structurally complex and functionally diverse oxazolone peptidomimetics, which contain α-acylamino carboxamide or β-amido ketone residues, is presented. Most of these molecules have lipophilicity constant values (log P) in the qualifying range for cell permeability, and that indicates the possibilities of these new molecules to be used in the search for potential inhibitors for a broad spectrum of enzymes. Copyright

An easy two step synthesis of macrocyclic peptidotriazoles via a four-component reaction and copper catalyzed intramolecular azide-alkyne [3+2] click cycloaddition

A two-step macrocyclization strategy for the synthesis of 12- and 14-membered cyclic peptidotriazoles by combining a one pot four-component reaction and an intramolecular [3+2] azide-alkyne click cycloaddition reaction is described. Macrocycles are obtained in good to excellent yield from the aqueous work-up of the reaction mixture and it is possible to expand or contract the ring size by adjusting the length of the nitrile moiety used in the MCR stage.

Stereoselective synthesis of bio-hybrid amphiphiles of coumarin derivatives by Ugi-Mannich triazole randomization using copper catalyzed alkyne azide click chemistry

An efficient synthesis of ester-triazole-amide amphiphiles of coumarin derivatives by triazole randomization based on click approach is described. Twenty-five small peptide azides were synthesized using Ugi or alternate Mannich-type multi-component reactions. The new azides were then used for the triazole randomization of alkyne functionalized coumarin ester under CuAAC conditions. Sixty-five new peptide bio-hybrids are obtained in near quantitative yield with high regio and stereoselectivity.