1375305-00-2

Upstream product

• 99-90-1 para-bromoacetophenone 
• 5651-86-5 4-(prop-2-ynyloxy)benzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 1370471-03-6 3-azido-N-[1-(2-bromophenyl)-3-(4-bromophenyl)-3-oxopropyl]propanamide 
• 1375304-79-2 C₂₀H₁₈ClNO₃ 
• 1375304-89-4 C₁₈H₁₆Br₃NO₂ 

Relevant academic research and scientific papers

An easy two step synthesis of macrocyclic peptidotriazoles via a four-component reaction and copper catalyzed intramolecular azide-alkyne [3+2] click cycloaddition

A two-step macrocyclization strategy for the synthesis of 12- and 14-membered cyclic peptidotriazoles by combining a one pot four-component reaction and an intramolecular [3+2] azide-alkyne click cycloaddition reaction is described. Macrocycles are obtained in good to excellent yield from the aqueous work-up of the reaction mixture and it is possible to expand or contract the ring size by adjusting the length of the nitrile moiety used in the MCR stage.