137565-20-9

Basic information

• Product Name: Lys-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂
• Synonyms: Lys-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂
• CAS NO: 137565-20-9
• Molecular Weight: 895.09
• Mol File: 137565-20-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Lys-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Lys-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂(137565-20-9)
• EPA Substance Registry System: Lys-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂(137565-20-9)

Safety Data

• Hazardous Substances Data: 137565-20-9(Hazardous Substances Data)

Upstream product

• 86060-87-9 Fmoc-Val-OPfp 
• 86060-85-7 Fmoc-Gly-OPfp 
• 71989-28-1 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine 
• 86060-88-0 N-(9-fluorenylmethoxycarbonyl)-L-leucine pentafluorophenyl ester 

Relevant articles and documents

Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists

The design and synthesis of potent and selective neurokinin NK-2 receptor agonists 12 (GR64349) and 31 are described, together with structure-activity relationships for related analogues.Compound 12 (EC50 = 3.7 nM at NK-2 receptors in the rat colon; selectivity >1000- and >300-fold with respect to NK-1 and NK-3 receptors, respectively) was derived by incorporation of a Gly-Leu γ-lactam conformational constraint into the C-terminal region of the neurokinin A octapeptide analogue 3>-NKA(3-10).Compound 31 (EC50 = 15 nM in rat colon) contains a novel fused-bicyclicconstraint at the corresponding site in the substance P hexapeptide analogue 6>-SP(6-11).