137593-52-3

Basic information

• Product Name: GR 64349
• Synonyms: GR 64349;LYS-ASP-SER-PHE-VAL-GLY-R-GAMMA-LACTAM-LEU-MET-NH2;[LYS3, GLY8-R-GAMMA-LACTAM-LEU9]NEUROKININ A (3-10);L-Lys-L-Asp-L-Ser-L-Phe-L-Val-N-[(3R)-1-[(R)-1-[[[(S)-1-(Aminocarbonyl)-3-(methylthio)propyl]amino]carbonyl]-3-methylbutyl]-2-oxo-3α-pyrrolidinyl]-NH2;L-Methioninamide,L-lysyl-L-a-aspartyl-L-seryl-L-phenylalanyl-L-valyl-(aS,3R)-3-amino-a-(2-methylpropyl)-2-oxo-1-pyrrolidineacetyl-
• CAS NO: 137593-52-3
• Molecular Formula: C₄₂H₆₈N₁₀O₁₁S
• Molecular Weight: 921.11
• Product Categories: AgonistPeptides for Cell Biology;Neuropeptides;Peptides for Cell Biology;Tachykinins
• Mol File: 137593-52-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 1342.8°Cat760mmHg
• Flash Point: 765.9°C
• Appearance: /
• Density: 1.31g/cm³
• Storage Temp.: −20°C
• PKA: 4.13±0.10(Predicted)
• CAS DataBase Reference: GR 64349(CAS DataBase Reference)
• NIST Chemistry Reference: GR 64349(137593-52-3)
• EPA Substance Registry System: GR 64349(137593-52-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 137593-52-3(Hazardous Substances Data)

Usage

Uses

GR 64349 acts as a potent and selective agonist at the NK-2 tachykinin receptor. Initiates changes in the colon, intestine and spinal cord.

Upstream product

• 82611-46-9 N-(tert-butoxycarbonyl)-D-methionyl-L-leucine methyl ester 
• 82611-48-1 (2S)-2-<(3R)-3-<(tert-butoxycarbonyl)amino>-2-oxopyrrolidin-1-yl>-4-methylpentanoic acid 
• 124202-00-2 (R)-2-<3-<(tert-butoxycarbonyl)amino>-2-oxo-1-pyrrolidinyl>-(S)-4-methylpentanoic acid methyl ester 
• 86060-87-9 Fmoc-Val-OPfp 
• 86060-92-6 N-α-Fmoc-L-phenylalanine pentafluorophenyl ester 
• 71989-28-1 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine 
• 143267-21-4 (R)-2-<3-<(tert-butoxycarbonyl)amino>-2-oxo-1-pyrrolidinyl>-(S)-4-methylpentanoic acid pentafluorophenyl ester 

Relevant articles and documents

Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists

The design and synthesis of potent and selective neurokinin NK-2 receptor agonists 12 (GR64349) and 31 are described, together with structure-activity relationships for related analogues.Compound 12 (EC50 = 3.7 nM at NK-2 receptors in the rat colon; selectivity >1000- and >300-fold with respect to NK-1 and NK-3 receptors, respectively) was derived by incorporation of a Gly-Leu γ-lactam conformational constraint into the C-terminal region of the neurokinin A octapeptide analogue 3>-NKA(3-10).Compound 31 (EC50 = 15 nM in rat colon) contains a novel fused-bicyclicconstraint at the corresponding site in the substance P hexapeptide analogue 6>-SP(6-11).