137609-04-2

Upstream product

• 2382-10-7 2,6-dichloro-9-methyl-9H-purine 
• 131490-67-0 1-methyl-5-<(thiocarbamoyl)amino>-1H-imidazole-4-carboxamide 
• 21343-04-4 5-amino-1-methyl-1H-imidazole-4-carboxamide 
• 131490-63-6 5-<amino>-1-methyl-1H-imidazole-4-carboxamide 
• 1198-33-0 9-methylxanthine 
• 7732-18-5 water 
• 598-54-9 copper (I) acetate 
• 64-18-6 formic acid 
• 77287-34-4 formamide 
• 86296-75-5 2-amino-6-(methylamino)-5-nitrosopyrimidin-4(3H)-one 
• 152833-01-7 O⁶-benzyl-9-methylguanine 
• 17495-12-4 2-amino-7-benzyl-1H-purin-6(7H)-one 
• 306302-08-9 2-amino-6-(1,2,4-triazol-4-yl)-9-H-purine 
• 1904-98-9 2,6-diaminopurine 

Downstream Products

• 2382-18-5 2-amino-9-methyl-1,9-dihydro-purine-6-thione 
• 56-41-7 L-alanin 
• 1140968-23-5 Cl₂CuHOC₆H₄(C₅H₄N)(CH₃)C₃N₂COOCH₃(C₅H₄N₅OCH₃) 
• 1274711-17-9 C₁₃H₁₂FN₅OS 
• 1274711-18-0 C₉H₁₃N₅OS 
• 99626-40-1 {((C₆H₅)3P)2(Cl)(H₂O)HIr(C₅H₂N₄(CH₃)(NH₂)(O))}⁽¹⁺⁾*C₄F₉SO₃^(1-) = {((C₆H₅)3P)2(Cl)(H₂O)(H)Ir(C₅H₂N₄(CH₃)(NH₂)(O))}SO₃C₄F₉ 
• 99626-35-4 chloro-hydrido-9-methylguanine-bis-(triphenylphosphine)-iridium(III)-tetrafluoroborate 
• 99626-38-7 chloro-dinitrogen-hydrido-9-methylguanidine-bis-(triphenylphosphine)-iridium(III)-nonafluorobutansulfonate 
• 2835-81-6 2-aminobutanoic acid 
• 101622-51-9 olomoucine 
• 158982-11-7 2-amino-6-benzylamino-9-purine 

Relevant academic research and scientific papers

2-Amino-6-(1,2,4-triazol-4-yl)-purine: A useful intermediate in the synthesis of 9-alkylguanines

2-Amino-6-(1,2,4-triazol-4-yl)purine, prepared from 2,6-diaminopurine, was regioselectively alkylated at position 9. Subsequent alkaline hydrolysis afforded 9-alkylguanines in high yield. (C) 2000 Elsevier Science Ltd.

New synthesis of 9-alkylguanines and their N2-substituted derivatives

A new method of synthesizing 9-alkyl guanines and their N2-substituted derivatives from 7-benzylguanine and its N2-substituted derivatives has been developed by quaternization with alkyl halides, dialkyl sulfates, or arenesulfonic acid esters, and subsequent removal of the benzyl protection by hydrogenation of the intermediate quaternary salts or of the betaines obtained from them. 1998 Plenum Publishing Corporation.

HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN

The present invention relates to the field of small molecule heterocyclic inhibitors of GTP cyclohydrolase (GCH-I), or a tautomer, prodrug, or pharmaceutically acceptable salt thereof. The invention also features pharmaceutical compositions of the compounds and the medical use of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, or neuropathic pain).

Universal Base

The present invention provides artificial universal base capable of base pairing nonspecifically with any of four kinds of natural nucleic acid bases (A, T, G, and C) without the function to specifically recognize pairing natural nucleic acid bases for base pair formation. Universal base capable of base paring nonspecifically with four kinds of natural nucleic acid bases, wherein the universal base has a structure represented by the following chemical formula: wherein R represents a monovalent group other than a hydrogen atom.

Process for the preparation of 9-substituted guanine derivatives

A process for the preparation of 9-substituted quanine derivatives of general formula (I), in which R is C1 -C4 -alkyl optionally substituted with one or more hydroxy groups, or R is (α), benzyl, ribosyl, 2'-deoxyribosyl or (CH2)n -OR1 where n is 1 or 2, and R1 is CH2 CH2 OH or (β) or salts thereof, in which a 1-substituted5-(thiocarbamoyl)amino-1H-imidazole-4-carboxamide of general formula (III), where R has the same meaning as in formula (I), is cyclized: a) by treatment with a heavy metal salt of the group of Cu-, Ag-, Pb- and Hg-salts in an aqueous alkaline medium containing at least for equivalents of OH-ions at a temperature form about 0° C. to the reflux temperature, or b) by treatment with a peroxy compound in an aqueous alkaline medium at a temperature of about 0°-30° C., whereafter (I) is isolated by treatment with a acid and, if desired, is converted into a salt. The invention further comprises intermediates for use in the preparation of the above-mentioned compounds.