1376129-01-9Relevant academic research and scientific papers
Rhodium-catalyzed enantioselective nucleophilic fluorination: Ring opening of oxabicyclic alkenes
Zhu, Jiangtao,Tsui, Gavin C.,Lautens, Mark
, (2012)
Done with 'F'lair: Enantioselective fluorination was achieved by Rh I-catalyzed ring opening of oxabicyclic alkenes using Et 3Na HF. The chiral fluorinated scaffolds were obtained under mild reaction conditions in standard glass vess
Asymmetric fluorination of enamides: Access to α-fluoroimines using an anionic chiral phase-transfer catalyst
Phipps, Robert J.,Hiramatsu, Kenichi,Toste, F. Dean
supporting information; experimental part, p. 8376 - 8379 (2012/06/30)
The use of a BINOL-derived phosphate as a chiral anionic phase-transfer catalyst in a nonpolar solvent allows the enantioselective fluorination of enamides using Selectfluor as the fluorinating reagent. We demonstrate that a wide range of stable and synthetically versatile α-(fluoro)benzoylimines can be readily accessed with high enantioselectivity. These compounds have the potential to be readily elaborated into a range of highly stereodefined β-fluoroamines, compounds that constitute highly valuable building blocks of particular importance in the synthesis of pharmaceuticals.
