1376219-91-8

Upstream product

• 50827-64-0 3,4-dimethyoxy-2-methylphenol 
• 133129-56-3 1,2-dimethoxy-4-(methoxymethoxy)benzene 
• 2033-89-8 3,4-dimethoxyphenol 
• 1376220-15-3 (3,4-dimethoxy-2-methylphenoxy)methyl methyl ether 
• 108-23-6 isopropyl chloroformate 
• 1308721-92-7 (3Z)-1-acetyl-3-[[4,5-dimethoxy-2-(methoxymethoxy)-3-methylphenyl]methylene]piperazine-2,5-dione 
• 1308721-90-5 4,5-dimethoxy-2-(methoxymethoxy)-3-methylbenzaldehyde 
• 1308721-86-9 2-hydroxy-3-methyl-4,5-dimethoxybenzaldehyde 

Downstream Products

• 1376219-93-0 C₃₇H₄₄N₂O₁₃S 

Relevant academic research and scientific papers

Chemistry of renieramycins. Part 12: An improved total synthesis of (±)-renieramycin G

An improved total synthesis of (±)-renieramycin G (1g) from readily available 2-hydroxy-3-methyl-4,5-dimethoxybenzaldehyde (7) in 21 steps (6.3% overall yield) is described. The synthesis features the concise construction of a pentacyclic framework using the stereoselective Pictet-Spengler type cyclization reaction of lactam (25) with ethyl diethoxyacetate, followed by the base-catalyzed epimerization of the C-1 stereo center of aldehyde (30a). The results of cytotoxicity studies are also presented.