137641-05-5

Usage

Uses

Herbicide.

InChI:InChI=1/C19H12F4N2O2/c20-13-7-9-14(10-8-13)24-18(26)16-5-2-6-17(25-16)27-15-4-1-3-12(11-15)19(21,22)23/h1-11H,(H,24,26)

Upstream product

• 153564-24-0 2-chloro-6-[3-(trifluoromethyl)phenoxy]pyridine 
• 201230-82-2 carbon monoxide 
• 371-40-4 4-fluoroaniline 
• 855-38-9 P(p-CH₃OC₆H₄)3 
• 98-17-9 3-Trifluoromethylphenol 
• 137640-94-9 6-chloro-N-(4-fluorophenyl)pyridin-2-amide 
• 1026960-27-9 6-(3'-(trifluoromethyl)phenoxy)pyridin-2-ol 
• 1285695-13-7 6-(3'-(trifluoromethyl)phenoxy)pyridin-2-yl 4-tosylate 
• 178108-94-6 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride 
• 1929-82-4 nitrapyrin 
• 4684-94-0 6-chloropicolinic acid 
• 199276-46-5 2-chloro-6-[1-methyl-3-(trifluoromethyl)pyrazol-5-yloxy]pyridine 

Downstream Products

• 1448777-03-4 N-(4-fluorophenyl)-5-isopropyl-6-(3-(trifluoromethyl)phenoxy)picolinamide 

Relevant academic research and scientific papers

HERBICIDAL COMPOSITIONS

The present invention provides compositions comprising herbicidally active compounds (A) and (B), where (A) represents one or more compounds of the general formula (I) or agrochemically compatible salts thereof [component (A)], and (B) represents one or more herbicides [component (B)]. The application further relates to a method and to the use of the herbicidal composition according to the invention for controlling harmful plants or for regulating growth.

Method for preparing picolinafen

The invention discloses a method for preparing picolinafen, and belongs to the field of pesticide original medicine technology. The method comprises the following steps that (1) 2-chlorine-6-nitrapyrin serves as a raw material, and acid catalysis hydrolysis is carried out to synthesize 2-chlorine-6-pyridine carboxylic acid; (2) under conditions of alkali 1, catalyst and organic solvent 1, etherification reaction is carried out on 2-chlorine-6-pyridine carboxylic acid and m-trifluoromethylphenol to obtain 2-(3-trifluoromethylphenoxy pendant)-6-picolinic acid; (3) the 2-(3-trifluoromethylphenoxypendant)-6-picolinic acid and di(trichloromethyl) dimethyl carboxylate are reacted in alkali 2 and organic solvent 2 to synthesize intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonylchloride; (4) the intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonyl chloride and 4-fluoroaniline are reacted in alkali 3 and organic solvent 2 to prepare the picolinafen. The method for preparing the picolinafen has the advantages that the content of the prepared picolinafen product is 98.1%, the yield of the prepared picolinafen product is 83%, synthesis conditions are mild and safe, the operation process is controlled easily, aftertreatment is simple and convenient, the wastewater quantity is less, and the method is a green synthetic method for preparing the picolinafen.

Preparation method of 2-substitured phenoxy-6-pyridine formyl chloride and preparation method for picolinafen

The invention provides a preparation method of 2-substitured phenoxy-6-pyridine formyl chloride and a preparation method for picolinafen. Bis(trichloromethyl) carbonic ester(triphosgene) is used as achloride agent for performing a chloroformylation reaction of 2-(3-trifluoromethylphenoxy)-6-pyridine carboxylic acid. The method is mild in synthesis condition, safe, easy to control an operating process, simple and convenient in post-processing, little in wastewater quantity, and environmentally friendly, and capable of avoiding using corrosive reactants of thionyl chloride and the like, reducing the emission of pollution gases of sulfur dioxide and hydrogen chloride and the like and the emission of wastewater, reducing the requirements to a device, and simplifying the operation, the preparation method is beneficial to improve a preparation method of a picolinafen herbicide, and has the extensive application prospect.

Synthesis method of picolinafen

The invention provides a synthesis method of picolinafen. The synthesis method comprises the following steps: reacting 2-chloro-6-trichloromethyl pyridine (formula II) with 3-trifluoromethyl phenol (formula III) to generate 2-(3-trifluoromethylphenoxyl)-6

SYSTEM PROVIDING CONTROLLED DELIVERY OF GASEOUS CO FOR CARBONYLATION REACTIONS

A carbonylation system comprising at least one carbon monoxide producing chamber and at least one carbon monoxide consuming chamber forming an interconnected multi-chamber system, said interconnection allowing carbon monoxide to pass from the at least one carbon monoxide producing chamber to the at least one carbon monoxide consuming chamber, said at least one carbon monoxide producing chamber containing a reaction mixture comprising a carbon monoxide precursor and a catalyst, said at least one carbon monoxide consuming chamber being suitable for carbonylation reactions, said interconnected multi- chamber system being sealable from the surrounding atmosphere during carbonylation.

Ex situ generation of stoichiometric and substoichiometric 12CO and 13CO and its efficient incorporation in palladium catalyzed aminocarbonylations

A new technique for the ex situ generation of carbon monoxide (CO) and its efficient incorporation in palladium catalyzed carbonylation reactions was achieved using a simple sealed two-chamber system. The ex situ generation of CO was derived by a palladium catalyzed decarbonylation of tertiary acid chlorides using a catalyst originating from Pd(dba)2 and P(tBu)3. Preliminary studies using pivaloyl chloride as the CO-precursor provided an alternative approach for the aminocarbonylation of 2-pyridyl tosylate derivatives using only 1.5 equiv of CO. Further design of the acid chloride CO-precursor led to the development of a new solid, stable, and easy to handle source of CO for chemical transformations. The synthesis of this CO-precursor also provided an entry point for the late installment of an isotopically carbon-labeled acid chloride for the subsequent release of gaseous [ 13C]CO. In combination with studies aimed toward application of CO as the limiting reagent, this method provided highly efficient palladium catalyzed aminocarbonylations with CO-incorporations up to 96%. The ex situ generated CO and the two-chamber system were tested in the synthesis of several compounds of pharmaceutical interest and all of them were labeled as their [ 13C]carbonyl counterparts in good to excellent yields based on limiting CO. Finally, palladium catalyzed decarbonylation at room temperature also allowed for a successful double carbonylation. This new protocol provides a facile and clean source of gaseous CO, which is safely handled and stored. Furthermore, since the CO is generated ex situ, excellent functional group tolerance is secured in the carbonylation chamber. Finally, CO is only generated and released in minute amounts, hence, eliminating the need for specialized equipment such as CO-detectors and equipment for running high pressure reactions.

PROCESS FOR THE PREPARATION OF PYRIDYLCARBOXYLIC AMIDES AND ESTERS

The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and R1 have the meanings given in claim 1, which comprises the following steps: (a) heating a mixture consisting essenti

Process for the preparation of arylamides of heteroaromatic carboxylic acids

A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: in which each Anis nitrogen or CRn(n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitrogen atoms are not bonded directly to one another; R1to R5, if present, independently of one another; C1-4-alkyl or aryl, one of the substituents R1to R5being a group of the formula —OR, in which R is an optionally substituted aromatic or heteroaromatic radical; R6is hydrogen or C1-4-alkyl; and R7is an optionally substituted aromatic or heteroaromatic radical. The amides are obtained from the corresponding heteroaromatic halogen compounds, the corresponding aromatic amines and carbon monoxide in the presence of palladium diphosphine complex. Compounds of this class (Formula I) are important herbicides.

Process for the preparation of arylamides of heteroaromatic carboxylic acids

A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: STR1 in which each An is nitrogen or CRn (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitro

Process for the preparation of arylamides of heteroaromatic carboxylic acids

A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: STR1 in which each An is nitrogen or CRn (n=1 to 5), with the proviso that at least one of the ring members is nitrogen and that two nitro