137643-31-3

Usage

Uses

Used in Pharmaceutical Industry:
(4-Benzylpiperazino)(1H-indol-3-yl)methanone is used as a compound for potential pharmaceutical applications due to its unique structure and the properties of its constituent groups. The benzylpiperazine group's psychoactive properties and the indole group's presence in various natural products and pharmaceuticals contribute to its potential for drug development.
Used in Research and Development:
In the field of scientific research, (4-Benzylpiperazino)(1H-indol-3-yl)methanone serves as a subject for further investigation. Its complex structure and the combination of psychoactive and pharmaceutically relevant groups make it a promising candidate for exploring new drug therapies and understanding its interactions with biological systems.

Upstream product

• 771-50-6 1H-indole-3-carboxylic acid 
• 2759-28-6 1-phenylmethylpiperazine 
• 120-72-9 indole 
• 67-66-3 chloroform 
• 1392831-25-2 (4-benzylpiperazin-1-yl)(imidazol-1-yl)methanone 

Relevant academic research and scientific papers

Indole-based heterocyclic inhibitors of p38α MAP kinase: Designing a conformationally restricted analogue

p38α Mitogen Activated Protein Kinase (MAP kinase) is an intracellular soluble serine threonine kinase. p38α kinase is activated in response to cellular stresses, growth factors and cytokines such as interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α). The central role of p38α activation in settings of both chronic and acute inflammation has led efforts to find inhibitors of this enzyme as possible therapies for diseases such as rheumatoid arthritis, where p38α activation is thought to play a causal role. Herein, we report structure-activity relationship studies on a series of indole-based heterocyclic inhibitors that led to the design and identification of a new class of p38α inhibitors.

Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group

Chloroform-mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the presence of air, the three-component aminocarbonylation reaction proceeded via in-situ generation of phosgene from chloroform and O2 to provide indole-3-carboxamides in a single operation. Application to the synthesis of biologically active compounds and intramolecular acylation are also described.

AlMe3-mediated regio- and chemoselective reactions of indole with carbamoyl electrophiles

Herein, we report the regio- and chemoselective reactions of indole with carbamoyl electrophiles in presence of AlMe3. Indole-3-carboxamide was prepared in one-step from a reaction of indole with tertiary carbamoylimidazole in the presence AlMe