1376607-66-7Relevant academic research and scientific papers
Protecting-group directed stereospecific organocatalytic [3+2] cycloadditions: A facile access to chiral spirocyclic oxindoles
Tan, Bin,Zhang, Xuan,Zhong, Guofu
, p. 124 - 142 (2014)
An efficient organocatalytic [3+2] cycloaddition between isocyanides and methyleneindolinones, with simultaneous formation of two quaternary stereocenters, for the rapid construction of dihydrospiro[pyrrolidin-3,3'- oxindole] derivatives with high enantiopurity and structural diversity was developed. Furthermore, different protecting group on the nitrogen atom of methyleneindolenones gave rise to a different major diastereoisomer, suggesting a new avenue of great importance to medicinal chemistry and diversity-oriented synthesis. ARKAT-USA, Inc.
Organocatalytic stereocontrolled synthesis of 3,3′-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones
Wang, Liang-Liang,Bai, Jian-Fei,Peng, Lin,Qi, Liang-Wen,Jia, Li-Na,Guo, Yun-Long,Luo, Xi-Ya,Xu, Xiao-Ying,Wang, Li-Xin
supporting information; experimental part, p. 5175 - 5177 (2012/06/18)
A stereoselective [3+2] cycloaddition of isocyanoesters to methyleneindolinones catalyzed by a quinine-based thiourea-tertiary amine has been successfully developed. Just by tuning the protecting groups on substrates, a variety of optically enriched 3,3′-
