1376609-82-3

Upstream product

• 2646-90-4 2,5-difluorobenzaldehyde 
• 951127-26-7 1-(2,5-difluorophenyl)-2-nitroethanol 
• 1245079-22-4 [(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1245079-21-3 [(3R,4S)-1-benzyl-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1376609-81-2 2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid methyl ester 
• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 956924-25-7 2-nitro-1-(2,4,5-trifluorophenyl)ethanol 
• 915100-66-2 (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene 

Downstream Products

• 1376609-97-0 {(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester 
• 1376610-75-1 {(3R,4S)-1-[5-({1-[3-(1,1-difluoroethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(2,2,2-trifluoroethyl)carbamoyl)pyrimidin-2-yl]-4-(2,5-difluorophenyl)pyrrolidin-3-yl}carbamic acid tert-butyl ester 
• 1376610-97-7 [(3R,4S)-1-{5-[(1-cyanopiperidin-4-yl)(cyclopropyl)carbamoyl]pyrimidin-2-yl}-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1376610-99-9 [(3R,4S)-1-[5-(cyclopropyl-{1-[5-(1,1-difluoroethyl)[1,2,4]oxadiazol-3-yl]piperidin-4-yl}carbamoyl)pyrimidin-2-yl]-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1376610-96-6 [(3R,4S)-1-{5-[(1-carbamoylpiperidin-4-yl)(cyclopropyl)carbamoyl]pyrimidin-2-yl}-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1376609-96-9 [(3R,4S)-4-(2,5-difluorophenyl)-1-(5-{[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl](methyl)carbamoyl}pyrimidin-2-yl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 
• 1376608-13-7 2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid [1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yl](methyl)amide 
• 1376610-98-8 [(3R,4S)-1-(5-{cyclopropyl-[1-(N-hydroxycarbamimidoyl)piperidin-4-yl]carbamoyl}pyrimidin-2-yl)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS

Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR1 19. Compounds having stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

1,4 DI SUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS

Therapeutic compounds are disclosed having the general formula (1) that are useful for the treatment of metabolic disorders, including type II diabetes.The compounds have activity as agonists of GPR1 19. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.