137669-33-1Relevant academic research and scientific papers
Transition-Metal-Free Annulation of Enamines and Tosyl Azide toward N-Heterocycle Fused and 5-Amino-1,2,3-Triazoles
Deng, Leiling,Liu, Yunyun,Zhu, Yanping,Wan, Jie-Ping
supporting information, p. 5606 - 5609 (2020/07/30)
The annulation reactions between gem-diamino enaminones (ketene aminals) and tosyl azide providing N-heterocycle fused and 5-amino side chain functionalized 1,2,3-triazoles have been developed. The synthesis of these N-side chain functionalized 1,2,3-tria
An efficient one-pot synthesis of heterocycle-fused 1,2,3-triazole derivatives as anti-cancer agents
Yan, Sheng-Jiao,Liu, Yong-Jiang,Chen, Yu-Lan,Liu, Lin,Lin, Jun
experimental part, p. 5225 - 5228 (2010/10/01)
A series of heterocycle-fused 1,2,3-triazoles were easily prepared by the 1,3-dipolar cycloaddition of heterocyclic ketene aminals or N,O-acetals with sodium azide and polyhalo isophthalonitriles in a one-pot reaction at room temperature without a catalyst and evaluated in vitro against a panel of human tumour cell lines. 1,3-Oxazoheterocycle fused 1,2,3-triazoles were more potent against the tumour cell lines Skov-3, HL-60, A431, A549 and HepG-2 than 1,3-diazoheterocycle fused 1,2,3-triazoles. 4-Methoxyphenyl substituted 1,3-oxazoheterocycle fused 1,2,3-triazole 6j was found to be the most potent derivative with IC50 values lower than 1.9 μg/mL against A431 and K562 human tumour cell lines.
The Reaction of Benzoyl-Substituted Heterocyclic Ketene Aminals with Aryl Azides
Huang, Zhi-Tang,Wang, Mei-Xiang
, p. 184 - 190 (2007/10/02)
The reaction between heterocyclic ketene aminals, 2-(benzoylmethylene)imidazolidines 3, -hexahydropyrimidines 4, and phenyl azides 5 was investigated.Both the reaction rate and products were strongly dependent on the substituents on 3 or 4 and 5.The react
