137693-34-6

Basic information

• Product Name: N-methylpyrrolidine-2-carboxamide
• Synonyms: N-methylpyrrolidine-2-carboxamide;N-METHYL-2-PYRROLIDINECARBOXAMIDE;N-methylprolinamide(SALTDATA: HCl);(S)-1-methylpyrrolidine-2-carboxamide hydrochloride;N-methylprolinamide hydrochloride
• CAS NO: 137693-34-6
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.174
• Mol File: 137693-34-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methylpyrrolidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methylpyrrolidine-2-carboxamide(137693-34-6)
• EPA Substance Registry System: N-methylpyrrolidine-2-carboxamide(137693-34-6)

Safety Data

• Hazardous Substances Data: 137693-34-6(Hazardous Substances Data)

Usage

General Description

N-methylpyrrolidine-2-carboxamide, also known as NMP, is a chemical compound with the molecular formula C6H11NO. It is a colorless to pale yellow liquid that is commonly used as a solvent in various industrial applications. NMP has a high solvency power and is used in the production of pharmaceuticals, polymers, and electronics. It is also used as a solvent for cleaning and degreasing applications. NMP is known for its ability to dissolve a wide range of substances and for its low volatility, making it a popular choice for various industrial processes. Despite its usefulness, NMP has been subject to regulatory scrutiny due to its potential health and environmental impacts, and alternatives are being sought in some applications.

Upstream product

• 144829-96-9 1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carboxylic acid 
• 88815-87-6 Boc-Pro-NHMe 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 5626-64-2 DL-Pro-NCA 
• 74-89-5 methylamine 

Downstream Products

• 53933-35-0 Piv-L-Pro-NHMe 
• 53933-35-0 Piv-Pro-NHMe 

Relevant articles and documents

IDO inhibitor as well as preparation method and application thereof

The present invention provides pharmaceutically acceptable salts, isomers, racemates, diastereomers, and pharmaceutical compositions of Formula I, Formula II, Formula III, or Formula IV and application thereof in treatment of indoleamine-(2,3)-dioxygenase-related diseases, specifically in the treatment of tumors, Alzheimer's disease, depression, cataracts and other various serious diseases; wherein R, R2, W and other groups are as shown in the specification. Preliminary drug activity studies show that the compounds have significant IDO inhibitory activity. Simultaneously, SD rats are used as test animals, concentrations of the compounds in the plasma at different time points after intragastric administration of the compounds in the rats are detected by LC/MS/MS method, pharmacokinetic behaviors of the compounds in the bodies of the rats are studied, results showed that the compounds have a significant pharmacokinetic absorption effect and have a good clinical application prospect.

CYCLOBUTENEDIONE DERIVATIVES

The present invention relates to compounds of the formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly inflammatory conditions.