5626-64-2Relevant academic research and scientific papers
Efficient preparation of proline N-carboxyanhydride using polymer-supported bases
Gulin, Oscar P.,Rabanal, Francesc,Giralt, Ernest
, p. 5385 - 5388 (2007/10/03)
A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest.
ENANTIOMERIC QUANTIFICATIONS OF AMINO ACIDS THROUGH THEIR Nα-ACYL AMIDES BY GAS CHROMATOGRAPHY.
Hosten, N.,Antenuis, M.J.O
, p. 48 - 50 (2007/10/02)
Apparent separation of 1.1 or higher on Chirasil Val III can be obtained for Nα-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns.A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from "in situ" silylated amino acids with trimethylsilyl cyanide.
