1377359-03-9Relevant academic research and scientific papers
Fluoride-mediated elimination of allyl sulfones: Application to the synthesis of a 2,4-dimethyl-A-ring vitamin D3 analogue
Sikervar, Vikas,Fleet, James C.,Fuchs, Philip L.
, p. 5132 - 5138 (2012)
A coupling strategy for the synthesis of 2,4-dimethyl-1α,25(OH) 2D3 is achieved which involves methylation of a pro-A ring vinyl sulfone and in situ traping of the allyl sulfonyl anion with a CD ring allyl chloride. TBAF-promoted 1,2-eliminative desulfonylation and concomitant silyl ether deprotection gives the vitamin D3 analogue.
