137782-15-1

Basic information

• Product Name: Benzenamine, N-(2,2-dimethylpropyl)-2-[(1H-imidazol-2-ylsulfinyl)methyl]-
• CAS NO: 137782-15-1
• Molecular Formula: C15H21N3OS
• Molecular Weight: 291.417
• Mol File: 137782-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenamine, N-(2,2-dimethylpropyl)-2-[(1H-imidazol-2-ylsulfinyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N-(2,2-dimethylpropyl)-2-[(1H-imidazol-2-ylsulfinyl)methyl]-(137782-15-1)
• EPA Substance Registry System: Benzenamine, N-(2,2-dimethylpropyl)-2-[(1H-imidazol-2-ylsulfinyl)methyl]-(137782-15-1)

Safety Data

• Hazardous Substances Data: 137782-15-1(Hazardous Substances Data)

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 137782-23-1 2-neopentylaminobenzyl alcohol 
• 3282-30-2 pivaloyl chloride 
• 84540-62-5 methyl N-trimethylacetylanthranilate 
• 137760-74-8 (2,2-Dimethyl-propyl)-[2-(1H-imidazol-2-ylsulfanylmethyl)-phenyl]-amine 

Relevant articles and documents

Synthesis and structure-activity relationships of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines as a new class of gastric H+/K+-ATPase inhibitors

A series of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines was synthesized and evaluated for its biological activity against H+/K+-ATPase prepared from rabbit stomach and gastric acid secretions in Heidenhain pouch dogs. Monoalkyl substituents on the nitrogen atom of the aniline moiety markedly inhibited the enzyme activity to the same degree as omeprazole, a representative H+/K+-ATPase inhibitor. Most of these compounds, administered at 3 mg/kg i.v. inhibited histamine-stimulated gastric acid secretion. The inhibitory activity of these derivatives on the enzymes at pH 6.0 was more potent than that at pH 7.4, and was distinctly correlated to stability in aqueous solution at pH 5.0.