137782-24-2

Usage

Structure

It is an aromatic compound with a hexylamino group (C6H13NH) attached to the second carbon of the benzene ring.

Application

Pharmaceutical Synthesis: Used as an intermediate in the synthesis of pharmaceuticals due to its functional group versatility.
Organic Compound Synthesis: Serves as a crucial intermediate in the synthesis of various organic compounds owing to its reactivity and functional groups.
Dye and Pigment Production: Employed in the manufacturing process of dyes, pigments, and other colorants.
Specialty Chemicals: Utilized in the production of specialty chemicals due to its role as a versatile building block.

Versatility

Known for its ability to function as a versatile building block in the synthesis of various organic compounds, enabling diverse applications in the chemical industry.

Upstream product

• 461396-27-0 methyl 2-hexanamidobenzoate 
• 111-26-2 hexan-1-amine 
• 18982-54-2 o-bromobenzyl alcohol 
• 134-20-3 2-carbomethoxyaniline 
• 142-61-0 Hexanoyl chloride 

Downstream Products

• 137782-09-3 Hexyl-[2-(1H-imidazol-2-ylsulfanylmethyl)-phenyl]-amine 
• 137782-16-2 Hexyl-[2-(1H-imidazole-2-sulfinylmethyl)-phenyl]-amine 

Relevant academic research and scientific papers

Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines

(Matrix presented) An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90°C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.

Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds

The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.

Synthesis and structure-activity relationships of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines as a new class of gastric H+/K+-ATPase inhibitors

A series of N-substituted 2-[(2-imidazolylsulfinyl)methyl]anilines was synthesized and evaluated for its biological activity against H+/K+-ATPase prepared from rabbit stomach and gastric acid secretions in Heidenhain pouch dogs. Monoalkyl substituents on the nitrogen atom of the aniline moiety markedly inhibited the enzyme activity to the same degree as omeprazole, a representative H+/K+-ATPase inhibitor. Most of these compounds, administered at 3 mg/kg i.v. inhibited histamine-stimulated gastric acid secretion. The inhibitory activity of these derivatives on the enzymes at pH 6.0 was more potent than that at pH 7.4, and was distinctly correlated to stability in aqueous solution at pH 5.0.