137782-35-5Relevant academic research and scientific papers
Potential Use of Carbocyclic Nucleosides for the Treatment of AIDS: Chemo-enzymatic Syntheses of the Enantiomers of Carbovir
Evans, Chris T.,Roberts, Stanley M.,Shoberu, Karoline A.,Sutherland, Alan G.
, p. 589 - 592 (2007/10/02)
The lactam (1R,4S)-2-azabicyclohept-5-en-3-one , derived by whole cell enantiospecific hydrolysis of the racemate was converted into (-)-carbovir (-)-1 in ten steps.Lipase catalysed acetylation of 4-cis-hydroxycyclopent-2-enylmethyl tripheny
Enzymatic Resolution of cis- and trans-4-Hydroxycyclopent-2-enylmethanol Derivatives and a Novel Preparation of Carbocyclic 2',3'-Dideoxydidehydronucleosides and Aristeromycin
Roberts, Stanley M.,Shoberu, Karoline A.
, p. 2605 - 2607 (2007/10/02)
The (1R,4S)-acetate 3 and the (1S,4S)-alcohol 5 have been obtained optically pure by lipase catalysed esterification: compounds 3 and 5 have been converted into carbocyclic dideoxydidehydronucleosides and aristeromycin 9.
