216481-88-8

Upstream product

• 10310-21-1 2-Amino-6-chloropurin 
• 10310-21-1 2-amino-6-chloropurine 
• 137821-19-3 (1R,4S)-(+)-4-acetoxy-1-(triphenylmethoxymethyl)cyclopent-2-ene 
• 110289-12-8 (+/-)-(1β,4β)-1-(triphenylmethoxymethyl)cyclopent-2-en-4-ol 
• 151765-20-7 (1S,5S)-5-hydroxymethyl-2-cyclopenten-1-ol 
• 159163-55-0 9-((1S,4R)-4-Benzyloxymethyl-cyclopent-2-enyl)-6-chloro-9H-purin-2-ylamine 
• 159248-77-8 Carbonic acid (1R,4S)-4-(2-amino-6-chloro-purin-9-yl)-cyclopent-2-enylmethyl ester methyl ester 
• 137782-35-5 (+)-cis-2-amino-6-chloro-9'-<(4'R)-(triphenylmethoxymethyl)cyclopent-2'-en-(1'S)-yl>purine 
• 267411-98-3 (4S,5R)-3-((1S,2S)-2-Benzyloxymethyl-2-ethoxy-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one 
• 261511-22-2 (1S)-cis-4-Benzyloxymethylcyclopent-2-en-1-ol 
• 267411-96-1 (4S,5R)-3-((1S,2R)-2-Benzyloxymethyl-4-oxo-cyclopentyl)-4,5-diphenyl-oxazolidin-2-one 
• 267411-95-0 (4S,5R)-3-((S)-2-Benzyloxymethyl-4-oxo-cyclopent-2-enyl)-4,5-diphenyl-oxazolidin-2-one 
• 267411-97-2 Carbonic acid (1S,4R)-4-benzyloxymethyl-cyclopent-2-enyl ester ethyl ester 

Downstream Products

• 124915-24-8 (+)-carbovir 
• 124915-24-8 (+)-carbovir 
• 128131-83-9 (+)-1592U89 

Relevant academic research and scientific papers

Practical enantiodivergent syntheses of both enantiomers of carbovir, 1592U89 and six-membered ring analogues

The hydroxylactones 4a-b (both available in optically pure form from biocatalytic processes) have been used in the preparation of carbovir, 1592U89, and their six-membered ring analogues.

A Novel, One-Pot Ring Expansion of Cyclobutanones. Syntheses of Carbovir and Aristeromycin

A novel, one-pot ring-expansion procedure was developed using Me3S(O)I, NaH, and Sc(OTf)3. The scope and limitations were briefly examined, and a tentative mechanism was proposed. Application of the methodology to known cyclobutanone 1 provided the corresponding cyclopentanone, which was successfully advanced to (+)-carbovir and (+)-aristeromycin.

[2+3]-cycloadditions of enantiomerically pure oxazoline-N-oxides1 : A short stereoselective synthesis of (+)-carbovir

A short stereo selective synthesis of the potent antiviral agent carbovir 1 has been achieved by using a new [2+3] asymmetric cycloaddition between oxazoline-N-oxide 3 and cyclopentadiene.

Potential Use of Carbocyclic Nucleosides for the Treatment of AIDS: Chemo-enzymatic Syntheses of the Enantiomers of Carbovir

The lactam (1R,4S)-2-azabicyclohept-5-en-3-one , derived by whole cell enantiospecific hydrolysis of the racemate was converted into (-)-carbovir (-)-1 in ten steps.Lipase catalysed acetylation of 4-cis-hydroxycyclopent-2-enylmethyl tripheny